NFL Week 2 injuries are already shaping the betting landscape, with key stars sidelined and lines moving dramatically ahead of Sunday and Monday’s games. The most impactful news: San Francisco 49ers quarterback Brock Purdy has been ruled out with a turf toe injury, forcing head coach Kyle Shanahan to turn to Mac Jones against the New Orleans Saints.
Brock Purdy out, 49ers offense in trouble
Purdy’s absence dropped San Francisco’s spread from -7 to -3, reflecting the sharp downgrade at quarterback. The 49ers are also dealing with multiple offensive injuries: wide receiver Brandon Aiyuk and tight end George Kittle are both sidelined, while Jauan Jennings and Trent Williams remain questionable. Oddsmakers have also cut the game total from 44.5 to 40.5, expecting a defensive grind.
Bills’ secondary battered
Buffalo cornerback Taron Johnson is questionable, though he has signaled he’ll play. The Bills, who gave up 40 points to the Ravens in Week 1, opened as -8.5 favorites over the Jets, but that line has slipped to -6.5. With secondary depth concerns, the Jets’ passing game and props on Garrett Wilson could gain betting value. The total has climbed from 44.5 to 47.5.
Eagles without Dallas Goedert
Philadelphia tight end Dallas Goedert has been ruled out for the Super Bowl 59 rematch with the Kansas City Chiefs. Goedert led the Eagles in Week 1 receptions, and his loss could be felt against a Chiefs defense that struggles against tight ends. The line has flipped from Chiefs -1.5 to Eagles -1.5, while the total sits at 46.5.
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Colts’ secondary woes
Indianapolis cornerback Charvarius Ward is out with a concussion, leaving the Colts shorthanded against Denver. The line has shifted from +3.5 to +2.5, reflecting uncertainty in the Colts’ depleted secondary. The total has edged down to 43.5.
Raiders’ Bowers expected to play
The Raiders received some good news: rookie tight end Brock Bowers is expected to play Monday night after practicing Saturday. The line remains Chargers -3, with the total steady at 46.5. If Bowers plays as expected, sharp bettors anticipate a small move back toward Las Vegas.
